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Read MoreUC-MSCs and treating lower back pain
Chronic pain, particularly low back pain, is a pervasive issue affecting millions. At Happy Valley, we understand the debilitating impact of this condition and are committed to exploring innovative solutions.
Low back pain, a common complaint, often stems from injuries, degenerative conditions, or spinal issues. While conventional treatments offer temporary relief, they often fail to address the root cause of the problem
The Limitations of Conventional Treatments:
- Medications can lead to dependency.
- Physical therapy and other therapies may not restore damaged tissue.
- Surgical interventions carry risks and lengthy recovery times
The Regenerative Promise of UC-MSCs:
Stem cell transplantation, particularly with mesenchymal stem cells (MSCs), offers a promising alternative. MSCs, with their ability to differentiate into various cell types, hold immense potential for tissue repair and regeneration.
Why UC-MSCs Stand Out:
- They possess anti-inflammatory properties.
- They have low immunogenicity, minimizing the risk of immune reactions.
- They multiply rapidly.
- They can differentiate into the three primary cell layers, crucial for tissue repair.
- They are harvested non-invasively.
- They have a low risk of tumor formation.
UC-MSCs and Spinal Disc Degeneration:
Research indicates that UC-MSCs can play a significant role in addressing spinal disc degeneration, a leading cause of low back pain.
- They can differentiate into nucleus pulposus cells, vital for disc health.
- They secrete factors that regenerate disc cells and reduce inflammation.
- Studies have shown improvements in pain and function in patients with discogenic back pain.
- Wharton’s Jelly stem cells, a type of UC-MSC, are very young and potent, making them excellent for regeneration.
Happy Valley's Approach:
At Happy Valley, we believe in addressing the root causes of chronic pain. UC-MSC therapy offers a unique opportunity to revitalize damaged spinal discs and restore function. By harnessing the body’s natural healing abilities, we aim to provide lasting relief and improve quality of life.
We are dedicated to staying at the forefront of regenerative medicine, offering innovative therapies that empower you to reclaim your well-being.
Works Cited:
- Rikard, S. M. (2023). Chronic Pain Among Adults—United States, 2019–2021. MMWR. Morbidity and Mortality Weekly Report, 72. https://doi.org/10.15585/mmwr.mm7215a1
- https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Low-Back-Pain
- Li, Z., Hu, X., & Zhong, J. F. (2019). Mesenchymal Stem Cells: Characteristics, Function, and Application. Stem cells international, 2019, 8106818.
https://doi.org/10.1155/2019/8106818 - Nishimura, T., Yamaguchi, S., Yoshimura, K., Rubinstein, P., & Takahashi, T. A. (2011). Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells from bone marrow and adipose tissue. Journal of cellular biochemistry, 112(4), 1206–1218.
https://doi.org/10.1002/jcb.23042 - Nagamura-Inoue, T., & He, H. (2014). Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility. World journal of stem cells, 6(2), 195–202.
https://doi.org/10.4252/wjsc.v6.i2.195 - Huang, H., Liu, X., Wang, J., Suo, M., Zhang, J., Sun, T., Zhang, W., & Li, Z. (2023). Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration. Frontiers in cell and developmental biology, 11, 1215698.
https://doi.org/10.3389/fcell.2023.1215698 - Pang, X., Yang, H., & Peng, B. (2014). Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain. Pain physician, 17(4), E525–E530. https://pubmed.ncbi.nlm.nih.gov/25054402/
- Richardson, S. M., Kalamegam, G., Pushparaj, P. N., Matta, C., Memic, A., Khademhosseini, A., … & Mobasheri, A. (2016). Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration.
Methods, 99, 69-80. https://doi.org/10.1016/j.ymeth.2015.09.015
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