We've all had those moments, gazing out a window, dreaming of fantastical abilities – flight, underwater breathing. While we may not possess superpowers, nature has provided us....
Read MoreRole of MSCs managing the immune system
Our immune system, a complex network of cells and molecules, diligently protects us from
harmful invaders. When functioning optimally, we’re unaware of its tireless work. However, when
compromised, it can lead to a range of health challenges.
Understanding the Immune System:
- It defends against pathogens like bacteria and viruses.
- It neutralizes harmful environmental substances.
- It combats disease-causing cellular changes, such as cancer.
The immune system distinguishes between “self” and “non-self” using proteins on cell membranes. When foreign antigens enter, the immune system activates.
It comprises two subsystems:
- Innate Immunity: This is our first line of defense, providing general protection.
- Adaptive Immunity: This system develops over time, producing antibodies that target
specific pathogens.
Immune System Disorders:
Dysfunction can manifest as:
- Immunodeficiency: A weakened immune system, leading to increased susceptibility to infections.
- Hypersensitivity: An overactive immune system, resulting in allergic reactions.
- Autoimmune Diseases: The immune system mistakenly attacks healthy cells, as seen in rheumatoid arthritis, multiple sclerosis, and others.
Conventional treatments often focus on symptom management, offering temporary relief.
The Regenerative Potential of UC-MSCs:
Stem cell therapy, particularly with umbilical cord-derived mesenchymal stem cells (UC-MSCs),
offers a promising approach to modulate the immune system.
Why UC-MSCs?
They can differentiate into various cell types.
- They possess immunomodulatory properties.
- They promote tissue repair and regeneration.
- They multiply rapidly.
- They have a low risk of triggering immune responses.
- They are easily collected.
UC-MSCs and Immune System Modulation:
Research suggests that UC-MSCs can:
- Enhance immune regulation and promote immune balance.
- Reduce inflammation in autoimmune conditions like rheumatoid arthritis.
- Improve outcomes in severe conditions like COVID-19.
- Reduce symptoms of graft-versus-host disease (GVHD).
Happy Valley's Approach:
At Happy Valley, we recognize the importance of a well-functioning immune system for overall health. UC-MSC therapy offers a unique opportunity to modulate immune responses and improve outcomes in various immune-related conditions.
By harnessing the immunomodulatory potential of UC-MSCs, we aim to provide innovative,
personalized therapies that promote immune health and well-being.
Works Cited:
- https://www.ncbi.nlm.nih.gov/books/NBK279364/
- https://my.clevelandclinic.org/health/diseases/21624-autoimmune-diseases
- Stem Cell Basics | STEM Cell Information. National Institutes of Health.
https://stemcells.nih.gov/info/basics/stc-basics - Stem Cells: Types, What They Are & What They Do. Cleveland Clinic.
https://my.clevelandclinic.org/health/body/24892-stem-cells - Lee, BC., Kang, KS. (2020) Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application. Stem Cell Res Ther 11, 397. https://doi.org/10.1186/s13287-020-01920-3
- Mebarki, M., Abadie, C., Larghero, J.. Cras, A. (2021). Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products. Stem Cell Res Ther 12, 152 (2021).
https://doi.org/10.1186/s13287-021-02222-y - Song, Y., Lim, J. Y., Lim, T., Im, K. I., Kim, N., Nam, Y. S., Jeon, Y. W., Shin, J. C., Ko, H. S., Park, I. Y., & Cho, S. G. (2020). Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different
mechanisms. World journal of stem cells, 12(9), 1032–1049.
https://doi.org/10.4252/wjsc.v12.i9.1032
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